MK-677: An Overview of its Effects on HGH and IGF-1

MK-677: An Overview of its Effects on HGH and IGF-1

 

MK-677, also known as Ibutamoren, has gained significant attention for its ability to naturally boost HGH (Human Growth Hormone) and IGF-1 (Insulin-like Growth Factor 1) levels. In this article, we’ll explore how MK-677 works, its effects on HGH and IGF-1, and the potential benefits it offers. This article dives into the science behind MK-677 and its effects on hormone production. We'll explore its performance-enhancing potential, anti-aging properties, and medical applications. Additionally, we'll examine MK-677 results, safety considerations, and what users can expect before and after use. To stay updated on fitness trends, check out our YouTube channel for more insights.

GHRH receptor agonism

MK-677 works by stimulating the GH secretagogue receptor (GHSR1a), also known as the ghrelin receptor. This receptor is found in the hypothalamus and pituitary ². When activated, it modulates both growth hormone-releasing hormone (GHRH) and somatostatin signaling to boost endogenous GH secretion ².

The compound's ability to enhance GH release is significant. Studies have shown that a single dose of MK-677 can lead to a peak in GH levels of 55.6 ng/ml ³. To put this in perspective, physiological GH peaks usually reach up to 10-14 ng/ml ³.

Ghrelin mimetic properties

As a ghrelin mimetic, MK-677 binds to ghrelin receptors in the pituitary gland. This binding triggers an increase in GH levels in the body ³. The compound's action is similar to that of ghrelin, a hormone produced in the stomach that plays a key role in regulating appetite and energy use ³.

MK-677's ghrelin-like effects extend beyond GH stimulation. It also has an influence on:

1. Appetite regulation
2. Energy distribution
3. Fat metabolism ³

Comparison to natural GH secretion

MK-677 stands out in its ability to augment endogenous GH pulsatility. In a study involving healthy elderly subjects, mean 24-hour GH concentrations increased with 10 and 50 mg doses of MK-677 ². This effect has also been observed in children with GH deficiency after a 6-month treatment period ².

Compared to natural GH secretion, MK-677 offers several advantages:

1. Oral bioavailability: Unlike most GHSs that require injections, MK-677 has an oral bioavailability of over 60% ³.
2. Extended half-life: MK-677's half-life exceeds 4-5 hours, allowing for sustained action ³.
3. Potent GH stimulation: In one study, MK-677 elicited greater GH responses than observed in GH deficiency diagnostic tests with various stimuli ².

The compound's efficacy in stimulating GH release is noteworthy. In a study, oral administration of MK-677 at 4 mg/kg significantly increased GH concentrations, with a 1.8-fold increase in peak GH concentration (45.7 ng/mL) ⁴. The GH area under the curve (AUC) showed a significant increase after administration of 4 mg/kg of MK-677, compared to the control group (1090 vs. 206 ng/min/mL, p<0.05) ⁴.

However, it's important to note that prolonged use of MK-677 may lead to desensitization. A study found that after 6 weeks of treatment, the initial GH stimulatory effect was abolished, possibly due to increased expression of somatostatin in the hypothalamus ⁴.

MK-677 and Growth Hormone Secretion

Acute effects on GH release

MK-677 has a powerful impact on growth hormone (GH) secretion, moreover single dose can lead to a significant increase in GH levels. Studies show that oral administration of 4 mg/kg MK-677 boosts GH concentrations by 1.8 times ⁴. The peak GH concentration reaches 45.7 ng/mL, a substantial rise from baseline levels ⁴.

The timing of this acute effect is noteworthy. After taking MK-677, GH levels peak at about 60 minutes. They then return to near-pretreatment levels within 120 minutes ⁴. This rapid response showcases MK-677's potent ability to stimulate GH release.

Comparing MK-677 to placebo further highlights its effectiveness. MK-677 produced a peak GH response of 55.9 ± 31.7 μg/L after the first dose. In contrast, placebo only resulted in a peak of about 9 μg/L ⁵. First and foremost, the difference underscores MK-677's potency in stimulating acute GH release.

Long-term impact on GH levels

The long-term effects of MK-677 on GH levels are complex. Initially, the compound maintains its GH-boosting properties. After a week of dosing, MK-677 still produced a peak GH response of 22.6 ± 9.3 μg/L. This was significantly higher than the placebo response of about 7 μg/L ⁵.

However, prolonged use may lead to changes in GH response. A study found that after 6 weeks of treatment, the initial GH stimulatory effect was abolished ⁴. This suggests a potential desensitization to MK-677's effects over time.

Despite this, MK-677 has a lasting impact on IGF-1 levels. IGF-1, a hormone stimulated by GH, increased progressively with MK-677 treatment. It reached 256 ± 84 ng/mL by day 3 and remained elevated throughout the treatment period ⁵. This sustained increase in IGF-1 levels indicates a persistent effect of MK-677 on the GH/IGF-1 axis.

IGFBP-3, another marker influenced by GH, also showed a significant increase during MK-677 treatment. It rose to 3374 ± 917 ng/mL by the fifth treatment day, a notable increase from baseline levels ⁵.

Factors affecting individual response

Several factors can influence an individual's response to MK-677. These include:

1. Duration of use: As mentioned earlier, prolonged use may lead to desensitization. The initial GH-boosting effect may diminish over time ⁴.

2. Dosage: The studies cited used specific doses (e.g., 4 mg/kg). Different doses may yield varying responses ⁴.

3. Individual physiology: Baseline GH and IGF-1 levels can affect the magnitude of response to MK-677.

4. Age and health status: These factors can influence how the body responds to GH stimulation.

5. Hypothalamic-pituitary axis function: The study found changes in hypothalamic somatostatin (SST) and pituitary somatostatin receptor (SSTR) expression with prolonged MK-677 use ⁴. These changes may affect long-term response.

To stay updated on the latest research about MK-677 and its effects on growth hormone, check out our YouTube channel: https://www.youtube.com/channel/UCcbdAECN1ik4XC8zgZA7z4w. We regularly post informative content on fitness and supplementation topics.

IGF-1 Production and MK-677

Mechanism of IGF-1 increase

MK-677, also known as ibutamoren, has a powerful impact on the growth hormone (GH) and insulin-like growth factor-1 (IGF-1) axis. This compound mimics the action of ghrelin, a hormone that stimulates GH release ¹. By activating the ghrelin receptor, MK-677 boosts GH secretion, which in turn leads to an increase in IGF-1 production.

Studies have shown that MK-677 can significantly elevate IGF-1 levels in various populations. In healthy older adults, GH-deficient adults, and GH-deficient children, daily oral administration of MK-677 increased serum GH, IGF-1, and IGF binding protein-3 (IGFBP-3) concentrations ⁴. This effect highlights the compound's potential to enhance the GH-IGF-1 axis across different age groups and conditions.

Time course of IGF-1 elevation

The time course of IGF-1 elevation with MK-677 use varies. In one study, IGF-1 levels increased progressively, reaching 256 ± 84 ng/mL by day 3 of MK-677 treatment ⁵. This elevation remained consistent throughout the treatment period. When comparing the mean value for the last 5 days of MK-677 treatment (264 ± 31 ng/mL) to the placebo group (188 ± 19 ng/mL), the difference was significant (P < 0.01) ⁵.

However, not all studies show consistent IGF-1 elevation. Another study reported that serum IGF-1 levels at 2, 4, and 6 weeks were unchanged compared to baseline ⁴. This discrepancy suggests that individual responses to MK-677 may vary, and the time course of IGF-1 elevation might not be uniform across all users.

Variability in IGF-1 response

The response to MK-677 in terms of IGF-1 production can be highly variable. Some individuals may experience significant increases, while others might see minimal changes. For example, one user reported a baseline IGF-1 level of 56 ng/mL (range 52-328 ng/mL) before starting MK-677 ⁶. After 7 weeks of taking 15mg nightly, their IGF-1 level increased to 75 ng/mL ⁶.

This variability in response could be due to several factors:

1. Individual physiology
2. Dosage and duration of use
3. Age and health status
4. Baseline IGF-1 levels

It's important to note that while MK-677 has shown promise in increasing IGF-1 levels, results may not be consistent across all users. Some individuals might experience rapid and significant increases, while others might see more modest or delayed effects.

In children with growth hormone deficiency, MK-677 performed better than other growth hormone secretagogues at improving growth hormone levels ¹. This suggests that the compound's effectiveness may also depend on the underlying condition or reason for use.

To stay updated on the latest research about MK-677 and its effects on IGF-1 production, check out our YouTube channel: https://www.youtube.com/channel/UCcbdAECN1ik4XC8zgZA7z4w. We regularly post informative content on fitness and supplementation topics.

Performance Enhancement Potential

MK-677, also known as ibutamoren, has gained attention for its potential to enhance athletic performance. This compound stimulates the release of growth hormone and IGF-1, leading to various benefits for athletes and fitness enthusiasts.

Strength Gains

MK-677 has shown promising results in increasing muscle mass and strength. In a study of 60-year-olds, growth hormone injections led to increased strength in thigh muscles ⁷. While MK-677 works differently, it stimulates natural growth hormone production, potentially yielding similar benefits.

Many users report observable enhancements in muscle density and overall size ⁸. Some have experienced weight gains of 10-15 pounds within weeks of usage ⁸. However, it's important to note that not all of this gain is pure muscle mass.

A two-month study involving 24 obese men showed that ibutamoren treatment increased lean mass ⁷. This suggests that MK-677 may help build and maintain muscle tissue, contributing to strength gains.

Endurance Improvements

While direct studies on MK-677's impact on endurance are limited, its effects on body composition and metabolism may indirectly improve endurance. MK-677 aids in increasing metabolic rates, allowing for more efficient caloric expenditure and weight management ⁸.

The compound reshapes body composition through multiple channels:

1. Refining nutrient partitioning
2. Amplifying lipolysis (fat breakdown)
3. Inducing muscular fullness due to increased nitrogen levels and water retention ⁸

These changes may lead to improved endurance by optimizing the body's energy utilization and reducing fatigue during prolonged physical activities.

Recovery Acceleration

One of the most significant benefits of MK-677 is its potential to accelerate recovery. The increased growth hormone and IGF-1 levels play a crucial role in this process.

1. Sleep Quality: Users often report marked improvement in sleep patterns. MK-677 seems to lengthen REM cycles, the deep, restorative phase of sleep where the body undergoes most of its recovery ⁸.

2. Tissue Regeneration: Elevated growth hormone levels allow the body to produce new cells faster while also healing damaged ones more quickly ⁸. This has positive implications for skin health, wound healing, and overall tissue maintenance.

3. Protein Catabolism Reversal: MK-677 has shown promise in alleviating muscle wasting caused by a decline in protein intake. In a study of healthy young adults, MK-677 effectively reversed protein catabolism ⁷.

4. Nitrogen Balance: MK-677 improved overall nitrogen balance over a 7-day treatment period. The nitrogen balance was +2.69 ± 5 g/day for MK-677 compared to −8.97 ± 5.26 g/day for placebo ⁵. This positive nitrogen balance is crucial for muscle repair and growth.

5. IGF-1 and IGFBP-3 Increase: IGF-1 levels increased progressively to 256 ± 84 ng/mL by day 3 of MK-677 treatment and remained elevated ⁵. IGFBP-3 also increased significantly during treatment ⁵. These factors contribute to faster recovery and tissue repair.

Users of MK-677 report faster recovery between workouts, allowing for more frequent and intense training sessions. After two weeks of treatment, many notice improvements in recovery speed ⁹. By the two-month mark, users typically experience a significant increase in well-being and energy, along with shorter recovery times between workouts ⁹.

It's important to note that while MK-677 shows promise for performance enhancement, individual results may vary. Factors such as diet, exercise regimen, and overall health can influence the compound's effectiveness. As with any performance-enhancing substance, it's crucial to consult with a healthcare professional before use.

To stay updated on the latest research about MK-677 and other fitness topics, check out our YouTube channel: https://www.youtube.com/channel/UCcbdAECN1ik4XC8zgZA7z4w. We regularly post informative content to help you optimize your fitness journey.

Anti-Aging Properties of MK-677

MK-677, also known as ibutamoren, has gained attention for its potential anti-aging properties. This growth hormone secretagogue stimulates the production of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) in the body ¹⁰. These hormones play crucial roles in various physiological processes, including tissue repair and regeneration.

Effects on skin elasticity

One of the most noticeable signs of aging is the loss of skin elasticity. MK-677 has shown promise in improving skin health and appearance. The increase in IGF-1 levels caused by MK-677 has been linked to improved skin elasticity and reduced wrinkles ¹¹. This effect is particularly beneficial for aging individuals looking to maintain a youthful appearance.

Studies have indicated that MK-677 may contribute to better skin health and reduced signs of aging ¹². The regenerative properties associated with increased growth hormone levels can lead to more youthful skin and faster healing. Users have reported improvements in skin elasticity as early as week 4 of MK-677 use ¹².

Impact on hair growth

MK-677's potential impact on hair growth is another exciting aspect of its anti-aging properties. The compound's ability to increase GH and IGF-1 levels may have a positive effect on hair follicles ¹⁰. IGF-1 plays a crucial role in the regulation of hair follicle development and maintenance.

The potential benefits of MK-677 for hair growth include:

1. Increased IGF-1 levels, which can stimulate hair follicles and encourage new hair growth ¹⁰.
2. Anti-inflammatory effects that may help reduce scalp inflammation, a common factor in hair loss ¹⁰.
3. Enhanced blood flow, which can nourish hair follicles and promote their health ¹⁰.
4. A shift from the telogen (resting) phase to the anagen (growth) phase of hair follicles, leading to thicker, healthier hair ¹⁰.

Many individuals have reported improvements in hair growth while taking MK-677, noting that their hair became thicker, shinier, and stronger ¹⁰.

Potential for longevity

The potential of MK-677 to contribute to longevity is a topic of great interest. As people age, there's a natural decline in growth hormone levels, which correlates with a decrease in fat-free mass (FFM) ¹³. This decline in FFM is associated with various age-related health issues, including frailty and loss of independence in the elderly ¹³.

A study involving healthy older adults found that daily administration of 25 mg of MK-677 significantly increased GH and IGF-I levels to those of healthy young adults without serious adverse effects ¹³. The study reported the following results:

• With placebo, mean FFM decreased by 0.5 kg, while with MK-677, it increased by 1.1 kg (P<0.001) ¹³.
• Body cell mass, reflected by intracellular water, decreased by 1.0 kg with placebo but increased by 0.8 kg with MK-677 (P=0.021) ¹³.

Another study involving 65 elderly men and women showed that daily ibutamoren increased GH and IGF-1 levels to those of healthy young adults without serious adverse effects ⁷. Similarly, a study with 24 obese males demonstrated that ibutamoren rejuvenated the growth hormone profile ⁷.

These findings suggest that MK-677 may help offset age-related declines in muscle mass and strength, potentially contributing to improved quality of life and longevity in aging individuals.

It's important to note that while MK-677 shows promise in various aspects of anti-aging, individual responses may vary. Some users report improved sleep quality and increased appetite, while others may experience minimal effects ¹⁴. As with any supplement, it's crucial to conduct thorough research and pay attention to your body's response.

To stay updated on the latest research about MK-677 and its anti-aging properties, check out our YouTube channel: https://www.youtube.com/channel/UCcbdAECN1ik4XC8zgZA7z4w. We regularly post informative content on fitness and supplementation topics.

MK-677 in Medical Applications

Treatment of growth hormone deficiency

MK-677, also known as ibutamoren, has shown promise in treating growth hormone deficiency (GHD). This oral secretagogue stimulates the release of growth hormone (GH) in the body ⁴. In children with GHD, a six-month study revealed promising results. The mean annualized growth velocity for MK-677 groups (6.0-6.9 cm/year) was higher than the placebo group (4.5 cm/year) ¹⁵.

However, it's important to note that MK-677's growth effects were less pronounced than injectable GH treatment (11.1 cm/year) ¹⁵. The study identified two predictive markers for increased height velocity on MK-677 treatment:

1. Peak GH ≥ 5 ng/mL to single dose
2. Baseline IGF-1 concentration > 30 ng/mL ¹⁵

Ibutamoren has demonstrated the ability to increase GH, IGF-1, and IGFBP-3 levels in children with GHD. These effects occur without significant changes in other hormones like prolactin, glucose, and thyroid hormones ⁷.

Potential for sarcopenia management

Sarcopenia, characterized by the decline in muscle mass and function with age, is a growing concern. MK-677 has shown potential in addressing this issue. A study involving healthy older adults found that daily oral administration of 25 mg MK-677 significantly increased GH and IGF-I levels ¹³.

Key findings from this study include:

1. MK-677 increased fat-free mass (FFM) by 1.1 kg, while placebo decreased FFM by 0.5 kg (P<0.001) ¹³.
2. Body cell mass increased by 0.8 kg with MK-677, compared to a decrease of 1.0 kg with placebo (P=0.021) ¹³.

These results suggest that MK-677 could potentially counteract the age-related decline in muscle mass. The compound addresses three key factors contributing to sarcopenia:

1. Reduced GH secretion
2. Fat-free mass loss
3. Inadequate food intake ¹⁶

However, it's crucial to note that while MK-677 shows promise, long-term functional studies in elderly adults are still needed ¹³.

Use in wasting diseases

MK-677 has demonstrated potential in treating catabolic conditions. A study found that MK-677 can reverse diet-induced nitrogen wasting ⁵. This suggests it might be useful in treating catabolic states caused by acute or chronic diseases.

The compound's ability to promote protein accretion makes it a potential treatment for conditions involving muscle wasting. In one study, MK-677 effectively reversed protein catabolism in healthy young adults ⁷. This finding supports its potential use in individuals suffering from catabolic conditions.

MK-677's anabolic effects, if sustained over several weeks, could potentially reduce the loss of skeletal muscle and visceral protein seen during catabolic states ⁵. However, further research is needed to establish whether these anabolic effects persist with prolonged treatment and if they translate to clinical benefits such as shorter hospital stays and accelerated convalescence ⁵.

It's important to note that while MK-677 shows promise in various medical applications, more research is needed. Long-term safety data and effects on bone age still require further study ¹⁵. Additionally, the compound's impact on insulin sensitivity and its safety profile in individuals with congestive heart failure need careful consideration ¹⁶.

To stay updated on the latest research about MK-677 and its medical applications, check out our YouTube channel: https://www.youtube.com/channel/UCcbdAECN1ik4XC8zgZA7z4w. We regularly post informative content on fitness and supplementation topics.

Safety Profile and Contraindications

Known side effects

MK-677, also known as ibutamoren, has several reported side effects. Users may experience an increase in appetite, which usually subsides within a few months ¹³. Transient, mild lower extremity edema and muscle pain are also common ¹³.

Other reported side effects include:

1. Lethargy
2. Joint pain (especially in those with pre-existing conditions)
3. Insulin resistance
4. Possible increase in prolactin levels ⁷

More serious side effects have been observed in clinical trials. MK-677 has been associated with:

1. Increased fasting blood glucose levels
2. Decreased insulin sensitivity
3. Reduced bone mineral density ¹⁷

In some cases, MK-677 use has led to increased cortisol levels. One study reported a cortisol increase of 47 (28 to 71) nmol/L [1.7 (1.0 to 2.6 µg/dL)] with MK-677 (P=0.020) ¹³.

Drug interactions

While specific drug interactions are not detailed in the provided information, it's crucial to consider potential risks when combining MK-677 with other substances. Of particular concern is the combination of MK-677 with SARMs (Selective Androgen Receptor Modulators).

When used together, MK-677 and SARMs could negatively impact:

1. Serum lipids
2. Liver enzymes
3. Testosterone levels ¹⁸

SARMs on their own are associated with serious safety concerns, including an increased risk of heart attack or stroke and life-threatening reactions such as liver damage ¹⁸.

Populations at risk

Certain populations may be at higher risk when using MK-677:

1. Individuals with heart conditions: At least one clinical trial of MK-677 was stopped early due to concerns that it might cause heart failure ¹⁹. The FDA lists ibutamoren as an ingredient that "poses significant safety risks due to the potential for congestive heart failure in certain patients" ¹⁸.

2. Diabetics or those at risk of diabetes: MK-677 has been shown to increase blood glucose levels, reduce insulin sensitivity, and increase glycated hemoglobin (HbA1c) ¹⁹.

3. Older adults: In a study involving elderly subjects, some participants required dose adjustments due to increased fasting glucose levels ¹³.

4. Athletes: MK-677 is banned in sports and considered a prohibited substance by the World Anti-Doping Agency (WADA) ¹⁷.

It's important to note that MK-677 is still considered an experimental drug. It has no approved uses in Australia and is listed in the Australian Poisons Standard ^19 17. The long-term safety of MK-677 is not established, and potential adverse effects may include those associated with growth hormone administration ¹⁸.

Given these concerns, individuals considering MK-677 use should be aware of the potential risks to their health. Athletes, in particular, need to understand that using MK-677 could result in anti-doping rule violations and lengthy sanctions ¹⁷.

To stay informed about the latest research on MK-677 and other fitness-related topics, subscribe to our YouTube channel: https://www.youtube.com/channel/UCcbdAECN1ik4XC8zgZA7z4w.

Conclusion

MK-677 has a significant impact on growth hormone and IGF-1 production in the body. Its potential to enhance performance, aid recovery, and slow down aging has sparked interest among athletes and researchers. However, users should be aware of possible side effects and contraindications.

While MK-677 shows promise in various medical applications, more research is needed to fully understand its long-term effects. To learn more about MK-677 and other fitness topics, check out our YouTube channel. For the best sources, visit https://solo.to/dadbod2fit.

FAQs

1. How does MK-677 influence IGF-1 levels in the body?
Taking 25 mg of MK-677 results in a significant increase in IGF-1 levels, with a 60.1% rise observed at 6 weeks and a 72.9% increase after 12 months.

2. Can MK-677 boost HGH levels?
Ibutamoren, commonly known as MK-677 or Nutrobal, elevates Human Growth Hormone (HGH) levels in the body. Although it is often promoted online for muscle building, it is officially classified as a poison.

3. What is the timeframe for seeing results from MK-677?
Results from MK-677 can be observed quite rapidly. In a study, daily nitrogen balance in the MK-677 treatment group increased significantly within the first week, showing a more positive balance compared to the placebo group.

4. Is it safe to use MK-677?
MK-677 is considered unsafe and poses health risks. It is banned in military use and is listed on both the Department of Defense Prohibited Dietary Supplement Ingredients List and the World Anti-Doping Agency Prohibited List.

References

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[14] - https://www.tiktok.com/discover/can-mk-677-cause-hair-loss?lang=en
[15] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8207831/
[16] - https://www.authorea.com/users/324107/articles/453547-major-approaches-the-use-of-gh-secretagogue-mk-677-for-muscle-mass-gain-in-elderly-a-brief-systematic-review
[17] - https://www.sportintegrity.gov.au/news/integrity-blog/2022-05/ibutamoren-mk-677-not-ok-dont-be-fooled-marketing
[18] - https://www.opss.org/article/performance-enhancing-substance-mk-677-ibutamoren
[19] - https://healthymale.org.au/health-article/what-you-need-to-know-about-mk-677-ibutamoren